Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Evaluation of EGFR and COX pathway inhibition in human colon organoids of serrated polyposis and other hereditary cancer syndromes.

Familial cancer - 1 Nov 2024

Kanth Priyanka, Hazel Mark W, Schell John C, Rutter Jared, Yao Ruoxin, Mills Alyssa P, Delker Don A

Abstract excerpt

Serrated polyposis syndrome (SPS) presents with multiple sessile serrated lesions (SSL) in the large intestine and confers increased colorectal cancer (CRC) risk. However, the etiology of SPS is not known. SSL-derived organoids have not been previously studied but may help provide insights into SPS pathogenesis and identify novel biomarkers and chemopreventive strategies. This study examined effects of EGFR and...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adenomatous Polyposis Coli
Share to Colon

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Colonic Polyps

Share to Colorectal Neoplasms, Hereditary Nonpolyposis

Share to Erlotinib Hydrochloride

Share to Neoplastic Syndromes, Hereditary

Share to Organoids

Share to Proto-Oncogene Proteins p21(ras)

Source

Open in PubMed Open full text

Identifiers

PMID: 38609520
DOI: 10.1007/s10689-024-00370-7
PMCID: PMC11512843

Genes

EGFR
FAP
BRAF
EGR1
FOSL1
FOXQ1
IL33
KRAS
MYC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Evaluation of EGFR and COX pathway inhibition in human colon organoids of serrated polyposis and other hereditary cancer syndromes.PMID 38609520Read ↗

Genetic editing of colonic organoids provides a molecularly distinct and orthotopic preclinical model of serrated carcinogenesis.Semantic proximity Read ↗

Phenotype and polyp landscape in serrated polyposis syndrome: a series of 100 patients from genetics clinics.Semantic proximity Read ↗

Colorectal Cancer Modeling with Organoids: Discriminating between Oncogenic RAS and BRAF Variants.Semantic proximity Read ↗

Multiplicity and Molecular Heterogeneity of Colorectal Carcinomas in Individuals With Serrated PolyposisSemantic proximity Read ↗

RNA Sequencing of Sessile Serrated Colon Polyps Identifies Differentially Expressed Genes and Immunohistochemical MarkersSemantic proximity Read ↗

Human colon organoids reveal distinct physiologic and oncogenic Wnt responsesSemantic proximity Read ↗

Gene Signature in Sessile Serrated Polyps Identifies Colon Cancer SubtypeSemantic proximity Read ↗

Sporadic and syndromic hyperplastic polyps and serrated adenomas of the colon: classification, molecular genetics, natural history, and clinical management.Semantic proximity Read ↗

Cancer Risk in Patients With and Relatives of Serrated Polyposis Syndrome and Sporadic Sessile Serrated Lesions.Semantic proximity Read ↗

Organoid cultures of early-onset colorectal cancers reveal distinct and rare genetic profiles.Semantic proximity Read ↗

Mutations in BRAF and KRAS differentially distinguish serrated versus non-serrated hyperplastic aberrant crypt foci in humans.Semantic proximity Read ↗

Serrated polyposis: colonic phenotype, extracolonic features, and familial risk in a large cohort.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.