Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Rapamycin rescues APC-mutated colon organoid differentiation

23 Jul 2025

Abstract excerpt

Familial adenomatous polyposis (FAP) is an autosomal dominant disorder characterized by germline mutations in the adenomatous polyposis coli (APC) gene. This leads to numerous colorectal adenomas and a high risk of colorectal cancer (CRC). Our stem cell-derived colon organoid model revealed that a heterozygous APC mutation is sufficient to induce colorectal cancer formation. We found a link between APC mutation...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Colorectal Cancer Treatments and Studies
Share to Genetic factors in colorectal cancer
Share to Lung Cancer Treatments and Mutations

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 40702333
DOI: 10.1038/s41417-025-00935-3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Rapamycin rescues APC-mutated colon organoid differentiationPMID 40702333Read ↗

Rapamycin Rescues APC-Mutated Colon Organoid DifferentiationSemantic proximity Read ↗

Colonic organoids derived from human induced pluripotent stem cells for modeling colorectal cancer and drug testing.Semantic proximity Read ↗

Heterozygous APC germline mutations impart predisposition to colorectal cancer.Semantic proximity Read ↗

Organoid cultures of early-onset colorectal cancers reveal distinct and rare genetic profiles.Semantic proximity Read ↗

Multi-omics, organoid-based modeling reveals an SRC/mTOR-dependent fetal-like stem cell trajectory in colorectal cancerSemantic proximity Read ↗

Shortcuts to intestinal carcinogenesis by genetic engineering in organoidsSemantic proximity Read ↗

BRAFV600E drives dedifferentiation in small intestinal and colonic organoids and cooperates with mutant p53 and Apc loss in transformation.Semantic proximity Read ↗

Modeling APC mutagenesis and familial adenomatous polyposis using human iPS cells.Semantic proximity Read ↗

Evaluation of EGFR and COX pathway inhibition in human colon organoids of serrated polyposis and other hereditary cancer syndromes.Semantic proximity Read ↗

Chir99021 and Valproic acid reduce the proliferative advantage of Apc mutant cells.Semantic proximity Read ↗

Genetic editing of colonic organoids provides a molecularly distinct and orthotopic preclinical model of serrated carcinogenesis.Semantic proximity Read ↗

Human colon organoids reveal distinct physiologic and oncogenic Wnt responsesSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.