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Article

Rough deal and Zw10 are required for the metaphase checkpoint in Drosophila.

Nature cell biology - 1 Dec 2000

Basto R, Gomes R, Karess R E

Abstract excerpt

The metaphase-anaphase transition during mitosis is carefully regulated in order to assure high-fidelity transmission of genetic information to the daughter cells. A surveillance mechanism known as the metaphase checkpoint (or spindle-assembly checkpoint) monitors the attachment of kinetochores to the spindle microtubules, and inhibits anaphase onset until all chromosomes have achieved a proper bipolar...

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PMID: 11146659
DOI: 10.1038/35046592

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Rough deal and Zw10 are required for the metaphase checkpoint in Drosophila.PMID 11146659Read ↗

The ZW10 and Rough Deal checkpoint proteins function together in a large, evolutionarily conserved complex targeted to the kinetochore.Semantic proximity Read ↗

A maternal effect rough deal mutation suggests that multiple pathways regulate Drosophila RZZ kinetochore recruitment.Semantic proximity Read ↗

Bipolar spindle attachments affect redistributions of ZW10, a Drosophila centromere/kinetochore component required for accurate chromosome segregation.Semantic proximity Read ↗

Mutations in the essential spindle checkpoint gene bub1 cause chromosome missegregation and fail to block apoptosis in Drosophila.Semantic proximity Read ↗

Drosophila CENP-A mutations cause a BubR1-dependent early mitotic delay without normal localization of kinetochore components.Semantic proximity Read ↗

The RZZ complex facilitates Mad1 binding to Bub1 ensuring efficient checkpoint signalingSemantic proximity Read ↗

Determinants of Drosophila zw10 protein localization and function.Semantic proximity Read ↗

Spindly switch controls anaphase: Spindly and RZZ functions in chromosome attachment and mitotic checkpoint controlSemantic proximity Read ↗

ZW10 helps recruit dynactin and dynein to the kinetochore.Semantic proximity Read ↗

The spindle checkpoint functions of Mad3 and Mad2 depend on a Mad3 KEN box-mediated interaction with Cdc20-anaphase-promoting complex (APC/C).Semantic proximity Read ↗

The Drosophila l(1)zw10 gene product, required for accurate mitotic chromosome segregation, is redistributed at anaphase onset.Semantic proximity Read ↗

Zwilch, a new component of the ZW10/ROD complex required for kinetochore functions.Semantic proximity Read ↗

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