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Spindly switch controls anaphase: Spindly and RZZ functions in chromosome attachment and mitotic checkpoint control

1 Feb 2011

Abstract excerpt

Spindly is a coiled-coil domain containing protein, also known as CCDC99, that is an important regulator of the mitotic checkpoint. It belongs to a functionally conserved family of proteins that controls the localization and function of cytoplasmic dynein at kinetochores. At kinetochores Spindly interacts with the RZZ (Rod/ZW10/Zwilch) complex and is required for the recruitment of cytoplasmic dynein to...

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PMID: 21252629
DOI: 10.4161/cc.10.3.14759

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Spindly switch controls anaphase: Spindly and RZZ functions in chromosome attachment and mitotic checkpoint controlPMID 21252629Read ↗

Rough deal and Zw10 are required for the metaphase checkpoint in Drosophila.Semantic proximity Read ↗

A maternal effect rough deal mutation suggests that multiple pathways regulate Drosophila RZZ kinetochore recruitment.Semantic proximity Read ↗

Zwilch, a new component of the ZW10/ROD complex required for kinetochore functions.Semantic proximity Read ↗

The RZZ complex integrates spindle checkpoint maintenance with dynamic expansion of unattached kinetochoresSemantic proximity Read ↗

A novel role of farnesylation in targeting a mitotic checkpoint protein, human Spindly, to kinetochores.Semantic proximity Read ↗

Beclin‐1 is required for chromosome congression and proper outer kinetochore assemblySemantic proximity Read ↗

Stable hZW10 kinetochore residency, mediated by hZwint-1 interaction, is essential for the mitotic checkpoint.Semantic proximity Read ↗

Kinetochore dynein generates a poleward pulling force to facilitate congression and full chromosome alignment.Semantic proximity Read ↗

The ZW10 and Rough Deal checkpoint proteins function together in a large, evolutionarily conserved complex targeted to the kinetochore.Semantic proximity Read ↗

Cdc42 and mDia3 regulate microtubule attachment to kinetochores.Semantic proximity Read ↗

The RZZ complex facilitates Mad1 binding to Bub1 ensuring efficient checkpoint signalingSemantic proximity Read ↗

Cdc14 inhibition by the spindle assembly checkpoint prevents unscheduled centrosome separation in budding yeast.Semantic proximity Read ↗

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