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Article

The ZW10 and Rough Deal checkpoint proteins function together in a large, evolutionarily conserved complex targeted to the kinetochore.

Journal of cell science - 1 Sept 2001

Scaërou F, Starr D A, Piano F, Papoulas O, Karess R E, Goldberg M L

Abstract excerpt

The zeste-white 10 (zw10) and rough deal (rod) genes of Drosophila both encode kinetochore components, and mutations in either gene greatly increase the missegregation of sister chromatids during mitosis. Here, we present genetic, cytological and biochemical evidence for a close, evolutionarily conserved relationship between the ROD and ZW10 proteins. We show that the phenotypes caused by disruption of either...

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Identifiers

PMID: 11590237
DOI: 10.1242/jcs.114.17.3103

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The ZW10 and Rough Deal checkpoint proteins function together in a large, evolutionarily conserved complex targeted to the kinetochore.PMID 11590237Read ↗

Rough deal and Zw10 are required for the metaphase checkpoint in Drosophila.Semantic proximity Read ↗

Zwilch, a new component of the ZW10/ROD complex required for kinetochore functions.Semantic proximity Read ↗

ZW10 helps recruit dynactin and dynein to the kinetochore.Semantic proximity Read ↗

A maternal effect rough deal mutation suggests that multiple pathways regulate Drosophila RZZ kinetochore recruitment.Semantic proximity Read ↗

Conservation of the centromere/kinetochore protein ZW10.Semantic proximity Read ↗

Stable hZW10 kinetochore residency, mediated by hZwint-1 interaction, is essential for the mitotic checkpoint.Semantic proximity Read ↗

Determinants of Drosophila zw10 protein localization and function.Semantic proximity Read ↗

Bipolar spindle attachments affect redistributions of ZW10, a Drosophila centromere/kinetochore component required for accurate chromosome segregation.Semantic proximity Read ↗

A conserved protein network controls assembly of the outer kinetochore and its ability to sustain tension.Semantic proximity Read ↗

Roles for the conserved spc105p/kre28p complex in kinetochore-microtubule binding and the spindle assembly checkpoint.Semantic proximity Read ↗

The Drosophila l(1)zw10 gene product, required for accurate mitotic chromosome segregation, is redistributed at anaphase onset.Semantic proximity Read ↗

The RZZ complex integrates spindle checkpoint maintenance with dynamic expansion of unattached kinetochoresSemantic proximity Read ↗

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