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Article

A maternal effect rough deal mutation suggests that multiple pathways regulate Drosophila RZZ kinetochore recruitment.

Journal of cell science - 15 Mar 2015

Défachelles Lénaïg, Hainline Sarah G, Menant Alexandra, Lee Laura A, Karess Roger E

Abstract excerpt

Proper kinetochore recruitment and regulation of dynein and the Mad1-Mad2 complex requires the Rod-Zw10-Zwilch (RZZ) complex. Here, we describe rod(Z3), a maternal-effect Drosophila mutation changing a single residue in the Rough Deal (Rod) subunit of RZZ. Although the RZZ complex containing this altered subunit (denoted R(Z3)ZZ) is present in early syncytial stage embryos laid by homozygous rod(Z3) mothers, it...

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Identifiers

PMID: 25616898
DOI: 10.1242/jcs.165712
PMCID: PMC4359924

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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A maternal effect rough deal mutation suggests that multiple pathways regulate Drosophila RZZ kinetochore recruitment.PMID 25616898Read ↗

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Zwilch, a new component of the ZW10/ROD complex required for kinetochore functions.Semantic proximity Read ↗

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