Article

Vitamin D-binding protein is required for the maintenance of α-cell function and glucagon secretion

2019-12-19

Abstract excerpt

<h4>ABSTRACT</h4> Vitamin D-binding protein (DBP) or GC-globulin carries vitamin D metabolites from the circulation to target tissues. DBP expression is highly-localized to the liver and pancreatic α-cells. While DBP serum levels, gene polymorphisms and autoantigens have all been associated with diabetes risk, the underlying mechanisms remain unknown. Here, we show that DBP regulates α-cell morphology, α-cell fun...

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Literature Corpus work: a89fea97-fb98-55c6-9038-454b25f04d0f
DOI: 10.1101/2019.12.19.881185

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