Article

Heterogeneous endocrine cell composition defines human islet functional phenotypes

2024-11-21

Abstract excerpt

<h4>SUMMARY</h4> Phenotyping and genotyping initiatives within the Integrated Islet Distribution Program (IIDP), the largest source of human islets for research in the U.S., provide standardized assessment of islet preparations distributed to researchers, enabling the integration of multiple data types. Data from islets of the first 299 organ donors without diabetes, analyzed using this pipeline, highlights subst...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 87df8ba9-41db-567c-97f2-854c6ccbaf26
DOI: 10.1101/2024.11.20.623809

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Heterogeneous endocrine cell composition defines human islet functional phenotypesDOI 10.1101/2024.11.20.623809Read

Heterogeneous endocrine cell composition defines human islet functional phenotypes.Semantic proximity Read

Molecular and functional profiling of human islets: from heterogeneity to human phenotypes.Semantic proximity Read

HumanIslets: An integrated platform for human islet data access and analysisSemantic proximity Read

Single-Cell Transcriptome Profiling of Human Pancreatic Islets in Health and Type 2 DiabetesSemantic proximity Read

Interrogating islets in health and disease with single-cell technologiesSemantic proximity Read

PanKbase Integrated Single-Cell Map: A Comprehensive Atlas of Human Pancreatic IsletsSemantic proximity Read

Single-cell decoding of human islet cell type-specific alterations in type 2 diabetes reveals converging genetic- and state-driven β-cell gene expression defectsSemantic proximity Read

Multi-omics profiling of living human pancreatic islet donors reveals heterogeneous beta cell trajectories towards type 2 diabetesSemantic proximity Read

A transcriptional cross species map of pancreatic islet cellsSemantic proximity Read

Pancreatic β-cell heterogeneity in health and diabetes: classes, sources, and subtypes.Semantic proximity Read

Integrated meta-analysis of public human pancreatic single-cell transcriptomes reveals distinct beta-cell state trajectories across aging and diabetesSemantic proximity Read

Aging of human endocrine pancreatic cell types is heterogeneous and sex-specificSemantic proximity Read