Article
Vitamin-D-Binding Protein Contributes to the Maintenance of α Cell Function and Glucagon Secretion.
Cell reports - 16 Jun 2020
Viloria Katrina, Nasteska Daniela, Briant Linford J B, Heising Silke, Larner Dean P, Fine Nicholas H F, Ashford Fiona B, da Silva Xavier Gabriela, Ramos Maria Jiménez, Hasib Annie, Cuozzo Federica, Manning Fox Jocelyn E, MacDonald Patrick E, Akerman Ildem, Lavery Gareth G, Flaxman Christine, Morgan Noel G, Richardson Sarah J, Hewison Martin, Hodson David J
Abstract excerpt
Vitamin-D-binding protein (DBP) or group-specific component of serum (GC-globulin) carries vitamin D metabolites from the circulation to target tissues. DBP is highly localized to the liver and pancreatic α cells. Although DBP serum levels, gene polymorphisms, and autoantigens have all been associated with diabetes risk, the underlying mechanisms remain unknown. Here, we show that DBP regulates α cell morphology,...
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