Article
Landmarks of human embryonic development inscribed in somatic mutations.
Science (New York, N.Y.) - 19 Mar 2021
Bizzotto Sara, Dou Yanmei, Ganz Javier, Doan Ryan N, Kwon Minseok, Bohrson Craig L, Kim Sonia N, Bae Taejeong, Abyzov Alexej, Park Peter J, Walsh Christopher A
Abstract excerpt
Although cell lineage information is fundamental to understanding organismal development, very little direct information is available for humans. We performed high-depth (250×) whole-genome sequencing of multiple tissues from three individuals to identify hundreds of somatic single-nucleotide variants (sSNVs). Using these variants as "endogenous barcodes" in single cells, we reconstructed early embryonic cell...
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