Article

Protein synthesis is suppressed in sporadic and familial Parkinson’s Disease by LRRK2

2020-04-28

Abstract excerpt

<h4>ABSTRACT</h4> Gain of function LRRK2-G2019S is the most common mutation associated with both familial and sporadic Parkinson’s disease. It is expected therefore that understanding the cellular function of LRRK2 will provide much needed insight on the pathological mechanism of sporadic Parkinson’s, which is the most common form. Here we show that constitutive LRRK2 activity represses nascent protein synthesis...

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Literature Corpus work: a887e5b8-b2be-5e73-81b9-205687b0e9b2
DOI: 10.1101/2020.04.27.053694

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