Article

Enhanced mTORC1 signaling and Protein Synthesis in Parkinson’s Disease Pathogenesis Disease Pathogenesis

2022-10-06

Abstract excerpt

Pathologic α-syn destabilizes the TSC 1 and 2 complex leading to mTORC1 activation, enhanced protein translation and neurodegeneration in PD. <h4>Abstract:</h4> Pathological α-synuclein (α-syn) plays an important role in the pathogenesis of α-synucleinopathies such as Parkinson’s disease (PD). Disruption of protein homeostasis is thought be central to PD pathogenesis, however the molecular mechanism of this dereg...

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Literature Corpus work: c08f6c26-58a5-538d-90e1-a98309322de3
DOI: 10.1101/2022.10.03.510455

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