Article

Constitutive Silencing of LRRK2 Kinase Activity Leads to Early Glucocerebrosidase Deregulation and Late Impairment of Autophagy in vivo

2021-06-16

Abstract excerpt

<title>Abstract</title> <p><bold>Background: </bold>Mutations in leucine-rich repeat kinase 2 (LRRK2) are associated with familiar and sporadic Parkinson’s disease. LRRK2 modulates the autophagy-lysosome pathway (ALP), a clearance process subserving the quality control of cellular proteins and organelles. Since dysfunctional ALP might lead to α-synuclein accumulation and, hence, Parkinson’s disease, LRRK2 kinase...

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Literature Corpus work: ea8bfdf1-4d39-5968-bd6c-6220350ee7b1
DOI: 10.21203/rs.3.rs-581412/v1

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