Article
Activity of translation regulator eukaryotic elongation factor-2 kinase is increased in Parkinson disease brain and its inhibition reduces alpha synuclein toxicity.
Acta neuropathologica communications - 2 Jul 2018
Jan Asad, Jansonius Brandon, Delaidelli Alberto, Bhanshali Forum, An Yi Andy, Ferreira Nelson, Smits Lisa M, Negri Gian Luca, Schwamborn Jens C, Jensen Poul H, Mackenzie Ian R, Taubert Stefan, Sorensen Poul H
Abstract excerpt
Parkinson disease (PD) is the second most common neurodegenerative disorder and the leading neurodegenerative cause of motor disability. Pathologic accumulation of aggregated alpha synuclein (AS) protein in brain, and imbalance in the nigrostriatal system due to the loss of dopaminergic neurons in the substantia nigra- pars compacta, are hallmark features in PD. AS aggregation and propagation are considered to...
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