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Article

Phosphorylation of 4E-BP by LRRK2 affects the maintenance of dopaminergic neurons in Drosophila.

The EMBO journal - 17 Sept 2008

Imai Yuzuru, Gehrke Stephan, Wang Hua-Qin, Takahashi Ryosuke, Hasegawa Kazuko, Oota Etsuro, Lu Bingwei

Abstract excerpt

Dominant mutations in leucine-rich repeat kinase 2 (LRRK2) are the most frequent molecular lesions so far found in Parkinson's disease (PD), an age-dependent neurodegenerative disorder affecting dopaminergic (DA) neuron. The molecular mechanisms by which mutations in LRRK2 cause DA degeneration in PD are not understood. Here, we show that both human LRRK2 and the Drosophila orthologue of LRRK2 phosphorylate...

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Identifiers

PMID: 18701920
DOI: 10.1038/emboj.2008.163
PMCID: PMC2543051

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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Phosphorylation of 4E-BP by LRRK2 affects the maintenance of dopaminergic neurons in Drosophila.PMID 18701920Read ↗

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