Article
Defects in mRNA Translation in LRRK2-Mutant hiPSC-Derived Dopaminergic Neurons Lead to Dysregulated Calcium Homeostasis.
Cell stem cell - 1 Oct 2020
Kim Jungwoo Wren, Yin Xiling, Jhaldiyal Aanishaa, Khan Mohammed Repon, Martin Ian, Xie Zhong, Perez-Rosello Tamara, Kumar Manoj, Abalde-Atristain Leire, Xu Jinchong, Chen Li, Eacker Stephen M, Surmeier D James, Ingolia Nicholas T, Dawson Ted M, Dawson Valina L
Abstract excerpt
The G2019S mutation in leucine-rich repeat kinase 2 (LRRK2) is a common cause of familial Parkinson's disease (PD). This mutation results in dopaminergic neurodegeneration via dysregulated protein translation, although how alterations in protein synthesis contribute to neurodegeneration in human neurons is not known. Here we define the translational landscape in LRRK2-mutant dopaminergic neurons derived from...
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