Article

Regulators of proteostasis are translationally repressed in fibroblasts from sporadic and LRRK2-G2019S Parkinson’s patients

2022-01-20

Abstract excerpt

<h4>ABSTRACT</h4> Parkinson’s disease (PD) is characterized by heterogeneous motor and non-motor symptoms. The majority of PD cases are sporadic, whereas the leucine-rich repeat kinase 2 (LRRK2) G2019S mutation is the most common monogenic cause of familial PD and symptomatically indistinguishable from the sporadic form. Deficits in protein synthesis have been reported in PD. However, it is not known which protei...

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Literature Corpus work: 334f3612-897e-5153-99c0-58d6a174d9a6
DOI: 10.1101/2022.01.17.476095

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