Article
Medulloblastoma exome sequencing uncovers subtype-specific somatic mutations.
Nature - 2 Aug 2012
Pugh Trevor J, Weeraratne Shyamal Dilhan, Archer Tenley C, Pomeranz Krummel Daniel A, Auclair Daniel, Bochicchio James, Carneiro Mauricio O, Carter Scott L, Cibulskis Kristian, Erlich Rachel L, Greulich Heidi, Lawrence Michael S, Lennon Niall J, McKenna Aaron, Meldrim James, Ramos Alex H, Ross Michael G, Russ Carsten, Shefler Erica, Sivachenko Andrey, Sogoloff Brian, Stojanov Petar, Tamayo Pablo, Mesirov Jill P, Amani Vladimir, Teider Natalia, Sengupta Soma, Francois Jessica Pierre, Northcott Paul A, Taylor Michael D, Yu Furong, Crabtree Gerald R, Kautzman Amanda G, Gabriel Stacey B, Getz Gad, Jäger Natalie, Jones David T W, Lichter Peter, Pfister Stefan M, Roberts Thomas M, Meyerson Matthew, Pomeroy Scott L, Cho Yoon-Jae
Abstract excerpt
Medulloblastomas are the most common malignant brain tumours in children. Identifying and understanding the genetic events that drive these tumours is critical for the development of more effective diagnostic, prognostic and therapeutic strategies. Recently, our group and others described distinct molecular subtypes of medulloblastoma on the basis of transcriptional and copy number profiles. Here we use...
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