Article

Defective DNA damage repair leads to frequent catastrophic genomic events in murine and human tumors

2018-05-04

Abstract excerpt

Chromothripsis and chromoanasynthesis are catastrophic events leading to clustered genomic rearrangements. Whole-genome sequencing revealed frequent chromothripsis or chromoanasynthesis (n= 16/26) in brain tumors developing in mice deficient for factors involved in homologous-recombination-repair or non-homologous-end-joining. Catastrophic events were tightly linked to Myc/Mycn amplification, with increased DNA d...

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Literature Corpus work: f83d758e-2238-5b99-b07d-786bf986ee71
DOI: 10.1101/314518

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