Article
Genomics of medulloblastoma: from Giemsa-banding to next-generation sequencing in 20 years.
Neurosurgical focus - 1 Jan 2010
Northcott Paul A, Rutka James T, Taylor Michael D
Abstract excerpt
Advances in the field of genomics have recently enabled the unprecedented characterization of the cancer genome, providing novel insight into the molecular mechanisms underlying malignancies in humans. The application of high-resolution microarray platforms to the study of medulloblastoma has revealed new oncogenes and tumor suppressors and has implicated changes in DNA copy number, gene expression, and...
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