Article

Intra-cellular accumulation of amyloid is a marker of selective neuronal vulnerability in Alzheimer’s disease

2023-11-24

Abstract excerpt

<h4>ABSTRACT</h4> Characterisation of vulnerable neurons that die earliest with Alzheimer’s disease (AD) could provide rationale treatment targets to slow or prevent neurodegeneration. We used imaging mass cytometry to identify the neuronal sub-types lost earliest in AD and explored associated mechanisms with paired single nuclear transcriptomics in post-mortem middle temporal gyri from diseased donors. We found L...

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Literature Corpus work: a8686ed8-d311-546e-b6fb-316cc53dcdea
DOI: 10.1101/2023.11.23.23298911

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