Article

AI supported in silico screening of chimeric antigen receptor therapy targets

2026-08-22

Abstract excerpt

Chimeric antigen receptor (CAR) cell therapy has achieved transformative clinical success through targeting of CD19 in refractory B cell malignancies, but extension of this strategy to solid tumors, other hematological malignancies, and autoimmune disease has exposed the complexity of target selection. Antigen abundance alone is not sufficient to define a suitable CAR target. Instead, therapeutic efficacy and safe...

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Literature Corpus work: 001bc1c9-554c-50dd-b970-d372f0d03f02
DOI: 10.64898/2026.08.21.746142

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