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Article

Alteration of Electrostatic Surface Potential Enhances Affinity and Tumor Killing Properties of Anti-ganglioside GD2 Monoclonal Antibody hu3F8.

The Journal of biological chemistry - 22 May 2015

Zhao Qi, Ahmed Mahiuddin, Guo Hong-fen, Cheung Irene Y, Cheung Nai-Kong V

Abstract excerpt

Ganglioside GD2 is highly expressed on neuroectodermal tumors and an attractive therapeutic target for antibodies that have already shown some clinical efficacy. To further improve the current antibodies, which have modest affinity, we sought to improve affinity by using a combined method of random mutagenesis and in silico assisted design to affinity-mature the anti-GD2 monoclonal antibody hu3F8. Using yeast...

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Identifiers

PMID: 25851904
DOI: 10.1074/jbc.M115.650903
PMCID: PMC4505556

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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