Structural and functional analysis of engineered antibodies for cancer immunotherapy: insights into protein compactness and solvent accessibility.

Abstract excerpt

Antibodies are crucial tools in various biomedical applications, including immunotherapy. In this study, we focused on designing and engineering antibodies to enhance their structural dynamics and functional properties. By employing advanced computational techniques and experimental validation, we gained crucial insights into the impact of specific mutations on the engineered antibodies. This study investigates...

Topics

• Protein Engineering
• Immunotherapy
• Humans
• Solvents
• Neoplasms
• Mutation
• Erb-b2 Receptor Tyrosine Kinases