Article

Improving type 2 diabetes polygenic risk scores by incorporating rare, low-frequency, and population-specific variants

2025-11-28

Abstract excerpt

Polygenic risk scores (PRSs) can improve type 2 diabetes (T2D) risk prediction beyond clinical risk factors, but most exclude low-frequency, rare, and population-specific variants. We hypothesized that incorporation of rare variants via large-scale, well-imputed or whole-genome sequence-based genome-wide association (GWAS) meta-analyses and expanded linkage disequilibrium (LD) reference panels would improve risk p...

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Literature Corpus work: a83f811e-14c8-52f4-8385-48ce4de27eda
DOI: 10.1101/2025.11.24.25340878

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