Article

A combined polygenic score of 21,293 rare and 22 common variants significantly improves diabetes diagnosis based on hemoglobin A1C levels

2021-11-09

Abstract excerpt

Polygenic scores (PS), constructed from the combined effects of many genetic variants 1 , have been shown to predict risk or treatment strategies for certain common diseases 2–6 . As most PS to date are based on common variants 7 , the benefit of adding rare variation to PS remains largely unknown and methodically challenging. We developed and validated a method for constructing a rare variant PS and applied it to...

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Literature Corpus work: 77d104b2-e701-586f-81f6-dd893b8ce3b5
DOI: 10.1101/2021.11.04.21265868

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