Article

Oncogenic Ras-Src-cortactin signaling rewires actin-generated forces to drive basement membrane rupture and initiate breast cancer invasion

2026-04-18

Abstract excerpt

Oncogenic HRas activation plays a fundamental role in tumorigenesis, yet the cellular mechanisms by which HRas downstream signaling drives basement membrane (BM) disruption during early breast cancer invasion remain unclear. Using HRas-inducible breast spheroids, we demonstrate that HRas rewires cellular mechanotransduction of tumor-associated extracellular matrix stiffening to promote invasion. This process occur...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: a8380a62-ad95-5a0e-86a5-4e581d3eb43f
DOI: 10.64898/2026.04.15.717430

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Oncogenic Ras-Src-cortactin signaling rewires actin-generated forces to drive basement membrane rupture and initiate breast cancer invasionDOI 10.64898/2026.04.15.717430Read

Amoeboid-Mesenchymal Transition and the Proteolytic Control of Cancer Invasion PlasticitySemantic proximity Read

LRP-1 promotes tumor progression of triple negative breast cancers by coordinating extracellular matrix remodeling and immune cell infiltrationSemantic proximity Read

DLC1 loss drives multicellular streaming invasion by enforcing spatially coordinated Rho and β1 integrin signalingSemantic proximity Read

Extracellular matrix rigidity controls breast cancer metastasis via TYK2-mediated mechanotransductionSemantic proximity Read

Proteostasis control via HSP90α sustains YAP activity to drive aggressive behaviours in cancer-associated fibroblastsSemantic proximity Read

Mechanisms of Basement Membrane Micro-Perforation During Cancer Cell Invasion Into a 3D Collagen GelSemantic proximity Read

Targeting stromal remodeling and cancer stem cell plasticity to overcome chemoresistance in triple negative breast cancerSemantic proximity Read

Temporal profiling of the breast tumour microenvironment reveals collagen XII as a driver of metastasisSemantic proximity Read

Matrix density-induced mechanoregulation of breast cell phenotype, signaling and gene expression through a FAK-ERK linkage.Semantic proximity Read

Oncogenic Src requires a wild-type counterpart to regulate invadopodia maturationSemantic proximity Read

Modeling Breast Cancer–Associated c-Src and EGFR Overexpression in Human MECs: c-Src and EGFR Cooperatively Promote Aberrant Three-dimensional Acinar Structure and Invasive BehaviorSemantic proximity Read

Mechanotransduction-Induced Gene Expression Reveals Activation of TGFβ/SKIL/TAZ Axis and Supports Invasive Phenotype in Triple-Negative Breast Cancer.Semantic proximity Read