Article

Mechanisms of Basement Membrane Micro-Perforation During Cancer Cell Invasion Into a 3D Collagen Gel

2022-08-12

Abstract excerpt

Cancer invasion through basement membranes represents the initial step of tumor dissemination and metastasis. However, little is known about how human cancer cells breach basement membranes. Here, we used a 3-dimensional in vitro invasion model consisting of cancer spheroids encapsulated by a basement membrane and embedded in 3D collagen gels to visualize the early events of cancer invasion by confocal microscopy...

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Literature Corpus work: b34e546a-4029-516e-9129-27f4c641ff2f
DOI: 10.20944/preprints202208.0242.v1

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