Article

Targeting stromal remodeling and cancer stem cell plasticity to overcome chemoresistance in triple negative breast cancer

2017-11-08

Abstract excerpt

<h4>ABSTRACT</h4> The cellular and molecular basis of stromal cell recruitment, activation and crosstalk in carcinomas is poorly understood, limiting the development of targeted anti-stromal therapies. In mouse models of triple negative breast cancer (TNBC), Hh ligand produced by neoplastic cells reprogrammed cancer-associated fibroblast (CAF) gene expression, driving tumor growth and metastasis. Hh-activated CAF...

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Literature Corpus work: 589f1f58-9091-59df-bea7-b281c116571e
DOI: 10.1101/215954

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