Article

Proteostasis control via HSP90α sustains YAP activity to drive aggressive behaviours in cancer-associated fibroblasts

2025-04-09

Abstract excerpt

<h4>ABSTRACT</h4> Cancers adapt proteostasis to cope with the burden of misfolded proteins, stabilize key signalling nodes and sustain their malignant behaviour. Tumour stroma is subjected to similar stresses, but how they influence its aberrant status remains unclear. We show that tumour stroma presents consistent upregulation of target genes associated to the major misfolding regulator HSP90 in cancer-associate...

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Literature Corpus work: aaf6fd5c-e32a-5729-8349-4f44632aa762
DOI: 10.1101/2025.04.04.647210

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