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LRP-1 promotes tumor progression of triple negative breast cancers by coordinating extracellular matrix remodeling and immune cell infiltration

2026-06-19

Abstract excerpt

<h4>Structural Abstract</h4> <h4>Background</h4> Triple-negative breast cancer (TNBC) represents a major clinical challenge due to its aggressiveness, heterogeneity and limited availability of effective targeted therapy. We investigated whether LRP-1, a multifunctional cell-surface endocytic and signaling receptor, contributes to TNBC progression. <h4>Methods</h4> Using CRISPR–Cas9, LRP-1-deficient murine 4T1 a...

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Literature Corpus work
118ede96-f2f3-5bea-88d0-35b1d5f859f8
DOI
10.64898/2026.06.17.732906
Open publication

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