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Article

Oncogenic Src requires a wild-type counterpart to regulate invadopodia maturation

28 Oct 2010

Abstract excerpt

The proto-oncogene Src tyrosine kinase (Src) is overexpressed in human cancers and is currently a target of anti-invasive therapies. Activation of Src is an essential catalyst of invadopodia production. Invadopodia are cellular structures that mediate extracellular matrix (ECM) proteolysis, allowing invasive cell types to breach confining tissue barriers. Invadopodia assembly and maturation is a multistep...

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PMID: 20980387
DOI: 10.1242/jcs.075200

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