Extracellular matrix rigidity controls breast cancer metastasis via TYK2-mediated mechanotransduction

Abstract excerpt

Mechanical cues from the extracellular matrix (ECM) regulate various cellular processes. In breast cancer, increased tumor stiffness is associated with elevated metastasis risk and poor survival. We identify a unique role of the JAK family kinase TYK2 in suppressing breast cancer metastasis under low ECM stiffness. Genetic or pharmacological inhibition of TYK2 in mammary acini and patient-derived organoids leads t...

Topics

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• Cell Adhesion Molecules Research
• Cell Movement
• Cytokine Signaling Pathways and Interactions
• Gene Expression Regulation, Neoplastic
• Intracellular Signaling Peptides and Proteins
• Kruppel-like factors research
• Mechanotransduction, Cellular
• Protein Tyrosine Phosphatases

Identifiers and source

Literature Corpus work

b1965211-3899-5235-a90c-1cad1d53a9c2

DOI

10.1101/2025.10.30.681251