Article

The inhibition of LSD1 via sequestration contributes to tau-mediated neurodegeneration

2019-08-27

Abstract excerpt

Tauopathies are a class of neurodegenerative diseases associated with pathological tau. Despite many advances in our understanding of these diseases, the direct mechanism through which tau contributes to neurodegeneration remains poorly understood. Previously, our lab implicated the histone demethylase LSD1 in tau-induced neurodegeneration by showing that LSD1 localizes to pathological tau aggregates in Alzheimer’...

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Literature Corpus work: a82d0cbb-2771-523e-86f5-8f5007958ed5
DOI: 10.1101/745133

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