Article
Tauopathies: Deciphering Disease Mechanisms to Develop Effective Therapies.
International journal of molecular sciences - 25 Nov 2020
Silva M Catarina, Haggarty Stephen J
Abstract excerpt
Tauopathies are neurodegenerative diseases characterized by the pathological accumulation of microtubule-associated protein tau (MAPT) in the form of neurofibrillary tangles and paired helical filaments in neurons and glia, leading to brain cell death. These diseases include frontotemporal dementia (FTD) and Alzheimer's disease (AD) and can be sporadic or inherited when caused by mutations in the MAPT gene....
Topics
- Alzheimer Disease
- Brain
- Cell Death
- Cytoskeleton
- Frontotemporal Dementia
- Humans
- Mutation
- Neurofibrillary Tangles
- Neuroglia
- Neurons
- Tauopathies
- tau Proteins