Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Phosphorylated Tau interacts with c-Jun N-terminal kinase-interacting protein 1 (JIP1) in Alzheimer disease.

The Journal of biological chemistry - 31 Jul 2009

Ittner Lars M, Ke Yazi D, Götz Jürgen

Abstract excerpt

In Alzheimer disease (AD) and frontotemporal dementia the microtubule-associated protein Tau becomes progressively hyperphosphorylated, eventually forming aggregates. However, how Tau dysfunction is associated with functional impairment is only partly understood, especially at early stages when T...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adaptor Proteins, Signal Transducing
Share to Alzheimer Disease
Share to Chlorocebus aethiops

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to COS Cells

Share to Kinesins

Share to Neurons

Share to Phosphorylation

Share to tau Proteins

Source

Open in PubMed Open full text

Identifiers

PMID: 19491104
DOI: 10.1074/jbc.M109.014472
PMCID: PMC2742856

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-19491104-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Phosphorylated Tau interacts with c-Jun N-terminal kinase-interacting protein 1 (JIP1) in Alzheimer disease.PMID 19491104Read ↗

Coordinated transport of phosphorylated amyloid-beta precursor protein and c-Jun NH2-terminal kinase-interacting protein-1.Semantic proximity Read ↗

Axonal Degeneration in Tauopathies: Disease Relevance and Underlying MechanismsSemantic proximity Read ↗

Bridging integrator 1 protein loss in Alzheimer’s disease promotes synaptic tau accumulation and disrupts tau releaseSemantic proximity Read ↗

Tau hyperphosphorylation impairs cooperative binding to microtubules and perturbs organelle trafficking in neuronsSemantic proximity Read ↗

Tau, microtubule dynamics, and axonal transport: New paradigms for neurodegenerative diseaseSemantic proximity Read ↗

Tau and tauopathies.Semantic proximity Read ↗

Frontotemporal Lobar Dementia Mutant Tau Impairs Axonal Transport through a Protein Phosphatase 1γ-Dependent Mechanism.Semantic proximity Read ↗

Interaction of tau protein with the dynactin complex.Semantic proximity Read ↗

Tau-tubulin kinase 1 enhances prefibrillar tau aggregation and motor neuron degeneration in P301L FTDP-17 tau-mutant mice.Semantic proximity Read ↗

hnRNP A1 , hnRNP A2B1 , and hnRNP K are dysregulated in tauopathies, but do not colocalize with tau pathologySemantic proximity Read ↗

Phosphorylated tau interactome in the human Alzheimer’s disease brainSemantic proximity Read ↗

Loss of the Alzheimer’s-linked bridging integrator 1 (BIN1) protein affects synaptic structure and disrupts tau localisation and releaseSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.