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The DNA methyltransferase 1 (DNMT1) acts on neurodegeneration by modulating proteostasis-relevant intracellular processes

2020-07-11

Abstract excerpt

The limited regenerative capacity of neuronal cells requires tight orchestration of cell death and survival regulation in the context of longevity, as well as age-associated and neurodegenerative diseases. Subordinate to genetic networks, epigenetic mechanisms, like DNA methylation and histone modifications, are involved in the regulation of neuronal functionality, and emerge as key contributors to the pathophysio...

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Literature Corpus work
773be92d-7430-52a8-86c7-54f5b1d99379
DOI
10.1101/2020.07.10.197442
Open publication

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The DNA methyltransferase 1 (DNMT1) acts on neurodegeneration by modulating proteostasis-relevant intracellular processesDOI 10.1101/2020.07.10.197442
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