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Microtubule-associated protein tau is essential for long-term depression in the hippocampus

2 Dec 2013

Abstract excerpt

The microtubule-associated protein tau is a principal component of neurofibrillary tangles, and has been identified as a key molecule in Alzheimer's disease and other tauopathies. However, it is unknown how a protein that is primarily located in axons is involved in a disease that is believed to have a synaptic origin. To investigate a possible synaptic function of tau, we studied synaptic plasticity in the...

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PMID: 24298146
DOI: 10.1098/rstb.2013.0144

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