Article

Transcriptional kinetics of X-chromosome upregulation

2019-02-05

Abstract excerpt

Ohno’s hypothesis postulates that X-chromosome upregulation rectifies X-dose imbalance relative to autosomal genes, present in two active copies per cell. Here we dissected X-upregulation into kinetics of transcription, inferred from allele-specific single-cell RNA-sequencing (scRNAseq) data from somatic mouse cells. We confirmed increased X-chromosome expression, and remarkably found that the X-chromosome achieve...

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Literature Corpus work: 3bbfd56e-0078-5066-89a9-a885291ab008
DOI: 10.1101/540104

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