Article

Aging of human endocrine pancreatic cell types is heterogeneous and sex-specific

2019-08-08

Abstract excerpt

<h4>Summary</h4> The human endocrine pancreas must regulate glucose homeostasis throughout the human lifespan, which is generally decades. We performed meta-analysis of single-cell, RNA-sequencing datasets derived from 36 individuals, as well as functional analyses, to characterize age-associated changes to the major endocrine pancreatic cell types. Increasing age was associated with shifts in pancreatic alpha an...

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Literature Corpus work: a80d5966-a876-572d-b39d-1fbbee775049
DOI: 10.1101/729541

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