Article

Single cell regulatory architecture of human pancreatic islets suggests sex differences in β cell function and the pathogenesis of type 2 diabetes.

2024-07-03

Abstract excerpt

<title>Abstract</title> Type 2 and type 1 diabetes (T2D, T1D) exhibit sex differences in insulin secretion, the mechanisms of which are unknown. We examined sex differences in human pancreatic islets from 52 donors with and without T2D combining single cell RNA-seq (scRNA-seq), single nucleus assay for transposase-accessible chromatin sequencing (snATAC-seq), hormone secretion, and bioenergetics. In nondiabeti...

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Literature Corpus work: b37f55f8-c67d-58a2-ba0e-5a756ca19024
DOI: 10.21203/rs.3.rs-4607352/v1

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