Article

Distinct senescent β-cell senotypes differentially drive islet aging and dysfunction

2026-05-28

Abstract excerpt

<h4>ABSTRACT</h4> Biological aging greatly impacts the body’s ability to handle glucose, and represents a major risk factor the development and progression of type 2 diabetes (T2D). Nonetheless, despite advances in cellular senescence research and the development of new senolytic therapies, the heterogeneity of cellular senescence in the human endocrine pancreas, as well as its roles in normal aging, remains to b...

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Literature Corpus work: 901fbed8-7601-5b4b-aaca-46e24c5ef92c
DOI: 10.64898/2026.05.25.727705

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