Article

Early induction of cytokine release syndrome by rapidly generated CAR T cells in a preclinical mouse model

2022-11-12

Abstract excerpt

<h4>Summary</h4> Chimeric antigen receptor (CAR) T cells have emerged as effective strategy against B cell malignancies. Since the long manufacturing process limits patient accessability, short-term (st) CAR T cells are under investigation. Here, we evaluated CD19-CAR T cells 24 hours after exposure to lentiviral vectors. In co-culture with tumor cells and monocytes, stCAR T cells exhibited anti-tumoral activity...

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Literature Corpus work: a64d63af-9200-5d57-845a-83c18b7fae5a
DOI: 10.1101/2022.11.12.515207

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