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Article

CAR T cells and T cells phenotype and function are impacted by glucocorticoid exposure with different magnitude.

Journal of translational medicine - 12 Mar 2024

Poiret Thomas, Vikberg Sara, Schoutrop Esther, Mattsson Jonas, Magalhaes Isabelle

Abstract excerpt

BACKGROUND: Chimeric antigen receptor (CAR) T cell therapy is associated with high risk of adverse events. Glucocorticoids (GCs) are cornerstone in the management of high-grade cytokine release syndrome (CRS) and immune effector cell-associated neurotoxicity syndrome (ICANS). Given the potentially deleterious effects of GCs on CAR T cells anti-tumor activity, increasing our understanding of GCs impact on CAR T...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 38475830
DOI: 10.1186/s12967-024-05063-4
PMCID: PMC10935894

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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