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Article

CAR-T Cell Therapy: Mechanism, Management, and Mitigation of Inflammatory Toxicities.

Frontiers in immunology - 1 Jan 2021

Fischer Joseph W, Bhattarai Nirjal

Abstract excerpt

Engineered T cell therapies such as chimeric antigen receptor (CAR) expressing T cells (CAR-T cells) have great potential to treat many human diseases; however, inflammatory toxicities associated with these therapies present safety risks and can greatly limit its widespread use. This article briefly reviews our current understanding of mechanisms for inflammatory toxicities during CAR T-cell therapy, current...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 34220853
DOI: 10.3389/fimmu.2021.693016
PMCID: PMC8250150

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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