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Article

Single-Cell Analysis of CAR-T Cell Activation Reveals A Mixed T H 1/T H 2 Response Independent of Differentiation

1 Apr 2019

Abstract excerpt

Abstract The activation mechanism of chimeric antigen receptor (CAR)-engineered T cells may differ substantially from T cells carrying native T cell receptor, but this difference remains poorly understood. We present the first comprehensive portrait of single-cell level transcriptional and cytokine signatures of anti-CD19/4-1BB/CD28/CD3ζ CAR-T cells upon antigen-specific stimulation. Both CD4+ helper T (TH) cells...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 31229590
DOI: 10.1016/j.gpb.2019.03.002

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