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Article

Multiparameter comparative analysis reveals differential impacts of various cytokines on CART cell phenotype and function ex vivo and in vivo.

Oncotarget - 13 Dec 2016

Xu Xiao-Jun, Song De-Gang, Poussin Mathilde, Ye Qunrui, Sharma Prannda, Rodríguez-García Alba, Tang Yong-Min, Powell Daniel J

Abstract excerpt

Exogenous cytokines are widely applied to enhance the anti-tumor ability of immune cells. However, systematic comparative studies of their effects on chimeric antigen receptor (CAR)-engineered T (CART) cells are lacking. In this study, CART cells targeting folate receptor-alpha were generated and expanded ex vivo in the presence of different cytokines (IL-2, IL-7, IL-15, IL-18, and IL-21), and their expansion,...

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Source

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Identifiers

PMID: 27409425
DOI: 10.18632/oncotarget.10510
PMCID: PMC5347696

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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