Article
Cockayne syndrome B protein acts as an ATP-dependent processivity factor that helps RNA polymerase II overcome nucleosome barriers.
Proceedings of the National Academy of Sciences of the United States of America - 13 Oct 2020
Xu Jun, Wang Wei, Xu Liang, Chen Jia-Yu, Chong Jenny, Oh Juntaek, Leschziner Andres E, Fu Xiang-Dong, Wang Dong
Abstract excerpt
While loss-of-function mutations in Cockayne syndrome group B protein (CSB) cause neurological diseases, this unique member of the SWI2/SNF2 family of chromatin remodelers has been broadly implicated in transcription elongation and transcription-coupled DNA damage repair, yet its mechanism remains largely elusive. Here, we use a reconstituted in vitro transcription system with purified polymerase II (Pol II) and...
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