Article

PSIP1/LEDGF reduces R-loops at transcription sites to maintain genome integrity

2022-12-02

Abstract excerpt

R-loops that accumulate at transcription sites pose a persistent threat to genome integrity. PSIP1 is a chromatin protein associated with transcriptional elongation complex, possesses histone chaperone activity, and is implicated in recruiting RNA processing and DNA repair factors to transcription sites. Here, we show that PSIP1 interacts with R-loops and other proteins involved in R-loop homeostasis, including PA...

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Literature Corpus work: b0b9f77c-cef7-5da8-931e-7065c72b5b00
DOI: 10.1101/2022.12.02.518862

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