Article

Co-Stimulatory Blockade Prevents Intragraft Accrual of Class-Switched, Activated B Cells Despite Failing to Prevent T-Cell Mediated Rejection

2025-10-24

Abstract excerpt

Previously, we defined the transcriptomes and clonality of intragraft CD8 + T cell during renal allograft rejection. Here, using single cell RNA sequencing (scRNAseq), we investigated non-CD8 + immune cells during T-cell-mediated rejection (TCMR) under different maintenance immunosuppression (mIS) regimens: tacrolimus, and co-stimulatory blockade (CoB) with belatacept (CTLA4-Ig) or iscalimab (anti−CD40). Myeloid...

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Literature Corpus work: a7af6416-375c-5b6f-a26f-7fe5bd1e49b5
DOI: 10.1101/2025.10.24.683156

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